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US 11,453,715 B2Granted
Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets
AssigneeNew York University
InventorsVictor J. Torres, Tamara Reyes-Robles, Francis Alonzo, III
Life of this patent
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Abstract
The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in a subject that involves administering compositions that inhibit S. aureus interaction with CXCR1/CXCR2 and DARC cellular receptors. The present invention further relates to novel compositions for carrying out these and other methods.
Claims7
A variant Leukocidin E (LukE) protein or polypeptide thereof of SEQ ID NO:4, said variant LukE protein or polypeptide comprising the amino acid sequence of residues 57-75 and 139-150 of SEQ ID NO:
- 4, and comprising one or more changes to the amino acid sequence of each of (i) residues 164-178 of SEQ ID NO:
- 4, (ii) residues 182-196 of SEQ ID NO:
- 4, and (iii) residues 237-271 of SEQ ID NO:
- 4.
1 more element
Dependencies are inferred from the claim text.