Back to results
US 11,453,713 B2Granted
Insertable variable fragments of antibodies and modified A1-A2 domains of NKG2D ligands
AssigneeXyphos Biosciences Inc.
InventorsKyle Landgraf, Daniel P. Steiger, Steven R. Williams, David W. Martin
Life of this patent
Estimating the term…
Abstract
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands.
Claims11
A non-natural, modified α1-α2 domain molecule from a human NKG2D ligand molecule, wherein said domain molecule comprises an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 17, and wherein in said domain molecule, the cysteine at position 103 in SEQ ID NO:
- 17 is replaced by serine, and the arginine at position 162 in SEQ ID NO:
- 17 is replaced by glycine.
Dependencies are inferred from the claim text.