HSP fusion protein with anti-chemorepellant agent for treatment of infectious disease
AssigneeThe General Hospital Corporation
InventorsMark C. Poznansky, Jeffrey A. Gelfand
Life of this patent
Estimating the term…
Abstract
This disclosure is directed to immune treatment of a disease (e.g., an infectious disease) using a fusion protein in combination with an anti-chemorepellant agent. In particular, the fusion protein comprises an antigen-binding domain (e.g., an antibody or antibody fragment) and a stress protein domain.
Claims14
A method for treating a tumor resulting from a viral infection in a patient wherein a virus from the viral infection induces or expresses chemorepellant properties, the method comprising:
- a) administering to the patient an effective amount of a fusion protein comprising a virus binding component and a stress protein component, wherein said virus binding component binds to the virus and said stress protein component activates antigen-presenting cells;
- and
- b) concurrently administering to said patient an effective amount of AMD3100;
- wherein the combination of the fusion protein and AMD3100 treats the tumor resulting from a viral infection,
- wherein the viral infection is human papillomavirus (HPV) infection.
A pharmaceutical composition for treating a tumor resulting from a viral infection comprising:
- (a) a fusion protein comprising a virus binding component wherein the virus binding component recognizes an antigen expressed by the tumor resulting from the viral infection, and a stress protein component;
- and
- (b) AMD3100,
- wherein the viral infection is human papillomavirus (HPV) infection.
A kit of parts for treatment of a tumor resulting from a viral infection in a patient, the kit comprising a therapeutically effective amount of AMD3100 and a fusion protein comprising a virus binding component and a stress protein component, wherein the virus binding component recognizes an antigen expressed by a tumor resulting from a viral infection, wherein the viral infection is human papillomavirus (HPV) infection.
Dependencies are inferred from the claim text.