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US 11,453,705 B2Granted
Multivalent particles compositions and methods of use
AssigneeAchelois Biopharma, Inc.
InventorsChang-Zheng Chen, Guoqiang Dong, Yiling Luo, Hua Zhou, Tian-Qiang Sun, Michael Chen
Life of this patent
Estimating the term…
Abstract
Provided herein are multivalent particles and compositions of multivalent particles for blocking viral infection.
Claims16
A multivalent particle comprising a fusion protein that comprises a mammalian polypeptide that binds to a viral protein and a transmembrane region of a transmembrane polypeptide wherein the fusion protein is expressed at least 10 copies on a surface of the multivalent particle, wherein the transmembrane polypeptide comprises an amino acid sequence that has at least 90% sequence identity to the amino acid sequence according to SEQ ID NO:
- 3 (Vesicular stomatitis virus G or VSVG) or an amino acid sequence that has at least 90% sequence identity to the amino acid sequence according to SEQ ID NO:
- 4 (SARS-COV-2 spike protein), and wherein the mammalian polypeptide comprises an amino acid sequence that has at least 90% sequence identity to the amino acid sequence according to SEQ ID NO:
- 1 (angiotensin-converting enzyme 2 or ACE2).
Dependencies are inferred from the claim text.