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AssigneeBicycleTx Limited
InventorsPaul Beswick, Liuhong Chen, Gemma Mudd, Peter Park, Katerine Van Rietschoten, Michael Rigby
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The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
A compound having the formula:
A pharmaceutical composition comprising a compound having the formula:
A method of treating a cancer in a patient, wherein the cancer is selected from bladder cancer, breast cancer, stomach cancer, esophageal cancer, lung cancer, ovarian cancer, and pancreatic cancer, comprising administering to the patient a compound having the formula:
Dependencies are inferred from the claim text.