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US 11,453,701 B2Granted
Tau aggregation peptide inhibitors
AssigneeAdrx, Inc.
InventorsShiho Tanaka, Ashley Wright, James Treanor, Marcin Apostol, Matthew A. G. Graf
Life of this patent
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Abstract
This invention relates to the field of tau aggregation inhibitors. More specifically, the invention relates to amyloid therapeutics. More specifically, the invention provides pharmaceutical compositions and methods of treating aggregation associated conditions or diseases with certain peptides.
Claims30
A peptide comprising:
- (a)
- (i) an amino acid sequence of formula IX:
- (IX)
- (PEPTIDE ID NO:
- 175)
- Xaa54-Xaa55-Xaa56-Xaa57-Xaa58-D-Trp
- wherein
- Xaa54 is selected from D-Trp, D-Glu, D-Thr, D-Lys and D-Arg;
- Xaa55 is selected from D-Arg, D-Ile, and D-Leu;
- Xaa56 is selected from D-Leu, D-Lys and D-Arg;
- Xaa57 is selected from D-Arg, D-Val, D-Ile and D-Leu;
- and
- Xaa58 is selected from D-Lys, D-Arg, and D-Val;
- or
- (ii) a variant of (i) in which one amino acid from Formula IX is replaced with a conservative substitution or a synthetic, or chemically modified cationic amino acid residue;
- (b) a C-terminal acid or amide of (a);
- or
- (c) an N-acetyl derivative of (a) or (b);
- or a pharmaceutically acceptable salt thereof,
- wherein the peptide inhibits aggregation of tau protein, and
- wherein the sequence is not PEPTIDE ID NO:
- 75.
19 more elements
Dependencies are inferred from the claim text.