Cyclic di-nucleotide compounds as sting agonists
AssigneeMerck Sharp & Dohme Corp.
InventorsMichael D. Altman, Brian Andresen, Wonsuk Chang, Jared N. Cumming, Ryan D. Otte, Benjamin Wesley Trotter
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Abstract
A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Claims10
A compound is selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
A compound, wherein the compound is selected from the group consisting of
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.