Adenosine analogs as methyltransferase inhibitors for treating cancer

A pharmaceutical composition, comprising

• a) a compound of formula I or II
• wherein:
• A is chosen from a direct bond and a (C1-C10)hydrocarbon;
• Y is N or CH;
• R2 is chosen from —H, and optionally substituted aryl and heteroaryl;
• R3 is chosen from
• —((CH2)m)aryl substituted with one to three substituents chosen independently from (C1-C6)alkoxy, halo(C1-C6)alkoxy, methylenedioxy, ethylendioxy, (C1-C6)acyl, (C1-C6)alkoxyalkyl, hydroxy(C1-C6)alkyl, hydroxy, carboxy, —C(═O)O—(C1-C6)alkyl], carboxamido, acetoxy, amino, (C1-C6)alkylamino, di(C1-C6)alkylamino, (C1-C6)alkylsulfonylamino, and arylsulfonylamino;
• —((CH2)m)heteroaryl optionally substituted with one to four substituents chosen independently from (C1-C6)alkoxy, halo(C1-C6)alkoxy, methylenedioxy, ethylendioxy, (C1-C6)acyl, (C1-C6)alkoxyalkyl, hydroxy(C1-C6)alkyl, hydroxy, carboxy, —C(═O)O—(C1-C6)alkyl], carboxamido, acetoxy, amino, (C1-C6)alkylamino, di(C1-C6)alkylamino, (C1-C6)alkylsulfonylamino, and arylsulfonylamino;
• R4 is chosen from —OH, —NH((CH2)m)aryl and —NH((CH2)m)heteroaryl, each said —NH((CH2)m)aryl or —NH((CH2)m)heteroaryl optionally substituted with one to three substituents chosen independently from (C1-C6)alkoxy, halo(C1-C6)alkoxy, methylenedioxy, ethylendioxy, (C1-C6)acyl, (C1-C6)alkoxyalkyl, hydroxy(C1-C6)alkyl, hydroxy, carboxy, —C(═O)O—(C1-C6)alkyl], carboxamido, acetoxy, amino, (C1-C6)alkylamino, di(C1-C6)alkylamino, (C1-C6)alkylsulfonylamino, and arylsulfonylamino;
• R5 is
• X1 is chosen from O, N, and S(═O)2;
• R1 is chosen from hydrogen, C1-C20 hydrocarbyl, C1-C20 oxaalkyl, C1-C20 thiaalkyl, C1-C20 azaalkyl, an optionally substituted benzoquinone, an optionally substituted hydrobenzoquinone, and phenyl substituted with at least one oxygenated substituent;
• R8 and R9 are chosen independently in each occurrence from H and (C1-C3)alkyl;
• m is 0 or an integer from 1 to 10;
• n is 1 or 2;
• p is an integer from 0 to 1 and q is an integer from 1 to 4, such that the sum of p and q is an integer from 1 to 4;
• and
• t is 0, 1, or 2;
• and
• b) a pharmaceutically acceptable excipient.