Substituted eneoxindoles and uses thereof

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• A is N or CR1;
• each R1, R2, and R3 is independently H, halogen, —CN, —N(R13)2, C1-C3 alkyl, C1-C3 haloalkyl, C2-C3 alkynyl, C1-C3 alkoxy, or —SO2R13, wherein the C2-C3 alkynyl is unsubstituted or substituted with 1, 2, or 3 R9 groups;
• one of B and E is
• and the other is J;
• J is H, —CN, C1-C3 alkyl, or C3-C6 cycloalkyl;
• wherein the C1-C3 alkyl or C3-C6 cycloalkyl is unsubstituted or substituted with 1, 2, or 3 R10 groups;
• is a group of formula
• wherein
• W is NR4 or S;
• X is N or CR5;
• Y is N or CR6;
• Z is N or CR7;
• X1 is NH;
• R4 is H;
• each R5, R6, and R7 is independently H, halogen, —CN, —CON(R8)2, —NR13C(O)R13, —SO2N(R13)2, C1-C3 alkyl, C1-C3 alkoxy, —N(R13)2, C3-C6 cycloalkyl, C6-C10 aryl, 5-10 membered heteroaryl having 1, 2, or 3 heteroatoms independently selected from N, O, and S, and 4-6 membered heterocyclyl having 1, 2, or 3 heteroatoms independently selected from N, O, and S;
• wherein the C1-C3 alkyl, C1-C3 alkoxy, C3-C6 cycloalkyl, C6-C10 aryl, 5-10 membered heteroaryl, or 4-6 membered heterocyclyl is unsubstituted or substituted with 1, 2, or 3 R11 groups;
• or wherein R5 and R6, or R6 and R7 together with atoms to which they are attached form a phenyl or a 5-6 membered heteroaryl having 1 or 2 heteroatoms independently selected from N, O, and S;
• wherein the phenyl or the 5-6 membered heteroaryl is unsubstituted or substituted with 1, 2, or 3 R11 groups;
• each R8 is independently H or C1-C3 alkyl, wherein the C1-C3 alkyl is unsubstituted or substituted with 1, 2, or 3 R12groups;
• or
• wherein two R8 groups together with the nitrogen they are attached to form a 4-6 membered heterocyclic ring having 1 or 2 heteroatoms selected from the group consisting of N, O, or S, wherein the 4-6 membered heterocyclic ring is unsubstituted or substituted with 1, 2, or 3 R12 groups;
• each R9 is independently —OR13, C1-C3 alkyl, or C3-C6 cycloalkyl;
• each R10 and R11 is independently selected from the group consisting of —OR13, halogen, CN, —N(R8)2, —CON(R8)2, —N(R13)COR13, —S(O)2R13, C1-C3 alkyl, C3-C6 cycloalkyl, 4-6 membered heterocyclyl having 1, 2, or 3 heteroatoms independently selected from N, O, and S, C6-C10 aryl, and 5-10 membered heteroaryl having 1, 2, or 3 heteroatoms independently selected from N, O, and S;
• each R12 is independently —OR13, C1-C3 alkyl, or —N(R13)2;
• wherein the C1-C3 alkyl is unsubstituted or substituted with 1, 2, or 3 groups independently selected from —OR13 and —N(R13)2;
• each R13 is independently H or C1-C3 alkyl, wherein the C1-C3 alkyl is unsubstituted or substituted with 1, 2, or 3 R22groups;
• each R22 is independently selected from the group consisting of halogen, —OH, C1-C3 alkyl, C1-C3 alkoxy, —NH2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2 wherein each C1-C3 alkyl is same or different, C3-C6 cycloalkyl, 4-6 membered heterocyclyl with 1, 2, or 3 heteroatoms selected from N, O, and S, C6-C10 aryl, and 5-10 membered heteroaryl having 1, 2, or 3 heteroatoms independently selected from N, O, and S;
• and
• is a group of formula:
• wherein L1 is N or CR19;
• n is 0, 1 or 2;
• m is 0, 1, or 2;
• p is 0, 1, 2, 3, 4, 5, or 6;
• R19 is H, —OR13, halogen, CN, —N(R13)2, or C1-C3 alkyl;
• each R20 is independently —OR13, halogen, CN, —N(R13)2, or C1-C3 alkyl;
• and
• each R21 is independently —OR13, oxo, halogen, CN, —N(R13)2, or C1-C3 alkyl;
• or two R21 groups on same or adjoining atoms are joined together to form a 3-6 membered carbocyclic ring or a 3-6 membered heterocyclic ring having 1 or 2 heteroatoms selected from N, O, and S.