Heterocyclic compound, preparation method and use thereof in medicine
AssigneeEvopoint Biosciences Co., Ltd.
InventorsYuchuan Wu, Xi Chen, Shaoqiang Huang, Yonghan Hu, Linhai Qu, Jinlian Zhu, Xiao Liu
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Abstract
Provided are a heterocyclic compound, a preparation method and the use thereof in medicine, and particularly involved are a heterocyclic compound for preventing and/or treating hypemricemia and gout, a preparation method and the use thereof in medicine. In particular, provided are a compound as shown in formula (I) and/or formula (II) or a tautomer thereof and a pharmaceutically acceptable salt thereof, a preparation method therefor and a method and the use thereof for treating hypemricemia and gout.
Claims3
A compound or the tautomer thereof or the pharmaceutically acceptable salt thereof, selected from the group consisting of:
- (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-7-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-yl)methanone;
- (6-bromo-2-ethylimidazo[1,2-a]pyrimidin-3-yl)(3,5-dibromo-4-hydroxyphenyl)methanone;
- (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-fluoroimidazo[1,2-a]pyrimidin-3-yl)methanone;
- (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-yl)methanone;
- (6-chloro-2-ethylimidazo[1,2-a]pyrimidin-3-yl)(3,5-dibromo-4-hydroxyphenyl)methanone;
- (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-7-(trifluoromethyl)imidazo[1,2-c]pyrimidin-3-yl)methanone;
- 3-bromo-5-(2-ethyl-6-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-carbonyl)-2-hydroxybenzonitrile;
- 3-bromo-5-(2-ethyl-6-fluoroimidazo[1,2-a]pyrimidin-3-carbonyl)-2-hydroxybenzonitrile;
- 5-(2-ethyl-6-fluoroimidazo[1,2-a]pyrimidine-3-carbonyl)-2-hydroxyisophthalonitrile 2,2,2-trifluoroacetate;
- 3-bromo-5-(2-ethyl-7-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-carbonyl)-2-hydroxybenzonitrile;
- (3-bromo-4-hydroxy-5-(trifluoromethyl)phenyl)(2-ethyl-6-fluoroimidazo[1,2-a]pyrimidin-3-yl)methanone;
- (3-bromo-4-hydroxy-5-(trifluoromethyl)phenyl)(2-ethyl-6-(trifluoromethyl)imidazo[1,2-a]pyrimidin-3-yl)methanone;
- (7-chloro-2-ethylimidazo[1,2-f]pyrimidin-3-yl)(3,5-dibromo-4-hydroxyphenyl)methanone;
- or tautomers or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.