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US 11,453,673 B2Granted
Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
AssigneeEli Lilly and Company
InventorsNicholas Paul Camp, Chafiq Hamdouchi, Jayana Pankaj Lineswala, John Richard Morphy, Qing Shi
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Abstract
The present invention provides a compound of Formula I: wherein R1 is methyl, ethyl or cyclopropyl; R2 is hydrogen, methyl, or ethyl; R3 is methyl or AA; and R4 is C2-C4 alkyl, BB; or a pharmaceutically acceptable salt thereof; for use as a PDE1 inhibitor.
Claims12
A compound of formula I:
- or a pharmaceutically acceptable salt or stereoisomer thereof,
- wherein:
- R1 is CH3, CH2CH3, or cyclopropyl;
- R2 is H, CH3, or CH2CH3;
- R3 is CH3 or CH2-(1-methylpyrazol-4-yl);
- and
- R4 is C2-C4 alkyl, 1-methylcyclopropyl, or tetrahydropyran-2-yl.
4 more elements
Dependencies are inferred from the claim text.