Pyrazolopyrimidine inhibitors of JAK kinases and uses thereof
AssigneeGenentech, Inc.
InventorsMark Edward Zak, Naomi S. Rajapaksa, Yun-Xing Cheng, Jessica Grandner, Daniel G. M. Shore, Marian C. Bryan
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Abstract
Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
Claims12
A compound or a stereoisomer thereof, wherein the compound, or stereoisomer thereof, is selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
The compound
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.