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US 11,453,657 B2Granted
Compounds for the treatment of parasitic infections
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsMaria Isabel Castellote Alvaro, Maria Luisa León Diaz, Jose Ignacio Martin Hernando
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Abstract
The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding compositions, and methods and/or uses in therapy, for example in the treatment of parasitic infections such as malaria, in particular infection by Plasmodium falciparum.
Claims19
A compound according to Formula (I) or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is hydrogen, fluoro or methyl, wherein
- when R1 is hydrogen, R2 is fluoro, methyl, hydroxyl or amino,
- when R1 is fluoro, R2 is fluoro, and
- when R1 is methyl, R2 is methyl or hydroxyl;
- R3 is hydrogen or fluoro;
- R4 is fluoro, chloro, cyano or methoxy;
- n is 1 or 2;
- and
- Het is imidazole, pyrazole, thiazole, isothiazole, oxazole, isoxazole, triazole or tetrazole, wherein each Het is optionally substituted by C1-C4 alkyl, cyano or —C(O)NH2.
7 more elements
A compound which is
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.