US 11,453,655 B2 · Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator

Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator

AssigneeVertex Pharmaceuticals Incorporated

InventorsAlexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou

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Abstract

Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Claims8

Dependent claims

Crystalline Form A of Compound 1:

Dependencies are inferred from the claim text.

Facts

Application

16/994,875Filed 17 Aug 2020 · division

Priority

9 Dec 2016

Published

US 2021/0047295 A118 Feb 2021

Granted

27 Sep 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
A61P 11/00
Drugs for disorders of the respiratory system
C07D 231/20
One oxygen or sulfur atom: one oxygen atom attached in position 3 or 5
C07D 401/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond

Family

Application62/432,537Us provisional application · filed 9 Dec 2016

Application15/836,627Parent of this division · filed 8 Dec 2017

US 2021/0047295 A1Pre-grant publication · published 18 Feb 2021

US 10,793,547 B2Parent of this division

US 2018/0162839 A1Published application

US 11,453,655 B2This patent

From the US filing history. Foreign family members aren’t listed.