Di-macrocycles

A di-macrocycle having the structure:

• wherein
• each of A1, A2, A3 and A4 is independently selected from:
• wherein
• L1, L2, L3, L4, L5, L6, L7, L8, and L9 are independently selected from C1, C2, C3, and C4 substituted or unsubstituted alkyl;
• and
• F1 and F2 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, a peptide and a nucleic acid
• each R7, and R8, R9 is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, CF3, —C(O)R17, —SO2NR17R18, —NR17R18, —OR17, —S(O)2R17, —COOR17, —S(O)2OR17, —OC(O)R17, —C(O)NR17R18, —NR17C(O)R18, —NR17SO2R18, and —NO2,
• wherein
• R7, and R8, together with the atoms to which they are attached, are optionally joined to form a ring system selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
• R17 and R18 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl;
• and
• R17 and R18, together with the atoms to which they are attached, are optionally joined to form a 5-, 6- or 7-membered ring.