Lipids for lipid nanoparticle delivery of active agents

A compound having the following structure (I):

• or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein:
• R1 is optionally substituted C1-C24 alkyl or optionally substituted C2-C24 alkenyl;
• R2 and R3 are each independently optionally substituted C1-C36 alkyl;
• R4 and R5 are each independently optionally substituted C1-C6 alkyl, or R4 and R5 join, along with the nitrogen atom to which they are attached, to form an optionally substituted heterocyclyl ring or an optionally substituted heteroaryl ring;
• L1, L2, and L3 are each independently optionally substituted C1-C18 alkylene;
• G1 is a direct bond, —(CH2)nO(C═O)—, —(CH2)n(C═O)O—, or —(C═O)—;
• G2 and G3 are each independently —(C═O)O— or —O(C═O)—;
• and
• n is an integer greater than 0.