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US 11,453,637 B2Granted
Site-specific isotopic labeling of 1,4-diene systems
AssigneeRetrotope, Inc.
InventorsDragoslav Vidovic, Mikhail Sergeevich Shchepinov
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Abstract
Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
Claims19
A composition comprising a compound having the formula:
- wherein R5 is H, C1-C5 alkyl, or a cation;
- and each Y is independently H, deuterium, or tritium, and at least one Y is deuterium or tritium, wherein the compound comprises at least 5% of the total number of molecules in the composition.
A composition comprising a compound having the formula:
- wherein R5 is H, C1-C5 alkyl, or a cation;
- and each Y is independently H, deuterium, or tritium, and at least one Y is deuterium or tritium, wherein the compound comprises at least 5% of the total number of molecules in the composition.
Dependencies are inferred from the claim text.