Production method for crystal of reduced coenzyme Q10 having excellent stability
AssigneeKaneka Corporation
InventorsTakao Yamaguchi, Koichi Kinoshita
Life of this patent
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Abstract
Provided is a production method capable of efficiently producing a reduced coenzyme Q10 Form II crystal. The method for producing a reduced coenzyme Q10 Form II crystal includes: adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a solution with a temperature of 32° C. to 43° C., the solution containing fa) at least one organic solvent selected from the group consisting of an alcohol, a hydrocarbon, an aliphatic acid ester and a nitrogen compound, and (b) reduced coenzyme Q10, to prepare a mixture, and precipitating the reduced coenzyme Q10 from the mixture, in the form of the reduced coenzyme Q10 Form II crystal.
Claims15
A method for producing a reduced coenzyme Q10 Form II crystal, comprising:
- adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a solution with a temperature of 32° C. to 43° C., said solution comprising (a) at least one organic solvent selected from the group consisting of an alcohol, a hydrocarbon, an aliphatic acid ester and a nitrogen compound, and (b) reduced coenzyme Q10, to prepare a mixture, and
- precipitating the reduced coenzyme Q10 from the mixture, in the form of the reduced coenzyme Q10 Form II crystal;
- wherein the reduced coenzyme Q10 Form II crystal is obtained with a Form II rate of 70-100%;
- or
- wherein the reduced coenzyme Q10 Form II crystal is obtained with a recovery rate of 78-99%.
Dependencies are inferred from the claim text.