Back to results
US 11,452,872 B2Granted
Neuromodulation device
AssigneesGalvani Bioelectronics Limited, Case Western Reserve University
InventorsAlessandra Giarola, Yee-Hsee Hsieh, Stephen J. Lewis, Arun Sridhar
Life of this patent
Estimating the term…
Abstract
This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
Claims17
An apparatus for treating sleep apnea in a subject, the apparatus comprising:
- i. at least two implantable neural interfacing elements each having one or more electrodes configured to deliver at least two independently selected electrical signals, wherein one neural interfacing element is configured to be in signaling contact with at least one of a left cervical sympathetic chain (CSC), a left superior cervical ganglion (SCG) or postganglionic branch thereof and wherein one neural interfacing element is configured to be in signaling contact with at least one of a right cervical sympathetic chain (CSC), a right superior cervical ganglion (SCG) or postganglionic branch thereof;
- and
- ii. a controller operably coupled to the at least two implantable neural interfacing elements, the controller programs the at least two implantable neural interfacing elements to deliver the electrical signals that increase localized sympathetic activity of the left CSC, left SCG or postganglionic branch thereof and the right CSC, the right SCG or postganglionic branch thereof, wherein the controller causes the at least two implantable neural interfacing elements having the at least one or more electrodes, which are positioned bilaterally, with one neural interfacing element placed on a left side of the subject and one neural interfacing element placed on a right side of the subject, to deliver the independently selected electrical signals to cause improvements in different parameters,
- wherein increased sympathetic activity of at least one of the CSC, SCG or postganglionic branch ameliorates sleep apnea in the subject.
1 more element
An apparatus for modulating neural activity of at least one of aa CSC, SCG or postganglionic branch of a subject, the apparatus comprising:
- at least two neural interfacing elements comprising one or more electrodes each neural interfacing element configured to apply an independently selected electrical signals wherein one neural interfacing element is t configured to be in signaling contact with at least one of a left cervical sympathetic chain (CSC), a left superior cervical ganglion (SCG) or postganglionic branch thereof and wherein one neural interfacing element is configured to be in signaling contact with at least one of a right cervical sympathetic chain (CSC), a right superior cervical ganglion (SCG) or postganglionic branch thereof;
- and
- a controller operably coupled to the at least two neural interfacing elements to provide bilateral stimulation with one neural interfacing element placed on a left side of the subject and one neural interfacing element placed on a right side of the subject, the controller controlling the independently selected signals to be applied by each of the at least two neural interfacing elements, such that the independently selected signals stimulate increased localized sympathetic activity in at least one of the CSC, SCG or postganglionic branch in the subject, and wherein the independently selected signals cause improvements in different parameters.
A method for increasing sympathetic activity of a subject comprising:
- implanting in the subject at least a portion of an apparatus for modulating (a) the neural activity of at least one of a left CSC, a left SCG or postganglionic branch of the subject and (b) the neural activity of at least one of a right CSC, a right SCG or postganglionic branch of the subject, the apparatus comprising:
- i. at least two neural interfacing elements for providing bilateral stimulation, each neural interfacing element -comprising one or more electrodes, wherein one of the at least two neural interfacing elements is configured to apply an independently selected electrical signal to at least one of the left CSC, the left SCG or postganglionic branch thereof of the subject and placed in signaling contact with at least one of the left CSC, the left SCG or postganglionic branch thereof, and further wherein one of the at least two neural interfacing elements is configured to apply an independently selected electrical signal to at least one of a right CSC, a right SCG or postganglionic branch thereof and is placed in signaling contact with at least one of a right CSC, the right SCG or postganglionic branch thereof;
- and
- ii. a controller operably coupled to the at least two neural interfacing elements, the controller controlling the independently selected signals to be applied by each of the at least two neural interfacing elements, such that the signals stimulate increased localized sympathetic activity;
- positioning one of the at least two neural interfacing elements of the apparatus in signaling contact with at least one of the left CSC, left SCG or postganglionic branch thereof of the subject;
- positioning one of the at least two neural interfacing elements neural interfacing elements of the apparatus in signaling contact with at least one of the right CSC, right SCG or postganglionic branch thereof of the subject;
- and
- activating the apparatus to cause an improvement in at least two parameters.
5 more elements
Dependencies are inferred from the claim text.