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US 11,452,862 B2Granted
Intersectional short-pulse electrical stimulation of the brain
AssigneesNew York University, University of Szeged
InventorsAntal Berenyi, Gyorgy Buzsaki
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Abstract
A system for electrical brain stimulation including a plurality of electrodes arranged around the patient's brain (either directly or indirectly through layers of dura, skull or skin) such that axes connecting each electrode pair intersect at a predetermined focal point, and a ground-independent switching circuit configured to selectively activate and deactivate electrodes via a plurality of ground-independent switches. Electrodes are sequentially activated and deactivated.
Claims20
A system for electrical brain stimulation comprising:
- a plurality of electrodes arranged in a plurality of electrode groups, each electrode group comprising two or more electrodes where at least one electrode is set to a different potential level such that a voltage difference is generated between members of an electrode group, the plurality of electrodes configured to be arranged on one of:
- an exterior surface of a patient's scalp,
- an exterior surface of the patient's skull,
- in the patient's skull, on the patient's brain or dura surface, or
- in the patient's brain;
- and
- a ground-independent switching circuit configured to selectively activate and deactivate electrode groups via at least one ground-independent switch;
- wherein axes connecting electrodes set to different potential levels within each electrode group or axes of generated electrical fields intersect at one or more predetermined focal points,
- wherein the ground-independent switching circuit is programmed to sequentially activate and deactivate electrode groups, and
- wherein the system utilizes the capacitive properties of a neuronal and/or glial cell membrane to implement a charge integrating mechanism, which temporally integrates an effect of multiple independent, sequential electrical pulses delivered through the two or more activated electrodes.
7 more elements
A method of electrical brain stimulation comprising;
- arranging a plurality of electrodes on an exterior surface of a patient's scalp, an exterior surface of the patient's skull, in the patient's skull, on the patient's brain or dura surface, or in the patient's brain in a plurality of electrode groups, each electrode group comprising two or more electrodes where at least one electrode is set to a different potential level such that a voltage difference is generated between members of an electrode group;
- and
- selectively activating and deactivating electrode groups via at least one ground-independent switch,
- wherein axes connecting electrodes are set to different potential levels within each electrode group or axes of generated electrical fields intersect at one or more predetermined focal points, and
- wherein the capacitive properties of neuronal and/or glial cell membranes are utilized to implement a charge integrating mechanism, which temporally integrates an effect of multiple independent, sequential electrical pulses delivered through the two or more activated electrodes.
2 more elements
Dependencies are inferred from the claim text.