Crosslinking submucosal injectate system

A method of treating a lesion site in a gastrointestinal tract;

• the method comprising:
• injecting a crosslinkable gel into a first tissue layer into and/or between fibers of the first tissue layer comprising delivering the gel at a pressure between about 0.25 psi and 5 psi, the crosslinkable gel increasing a volume of the first tissue layer;
• providing an electrostatic crosslinker;
• and
• resecting a portion of the first tissue layer having the increased volume away from a second tissue layer creating an exposed region in a remaining portion of the first tissue layer and leaving a portion of the gel covering at least a portion of the exposed region of the first tissue layer;
• crosslinking the portion of the gel to form a crosslinked gel by adding the electrostatic crosslinker to the crosslinkable gel that is in and/or between fibers of the first tissue layer, in a manner providing a protective crosslinked gel coating of said portion of the exposed region of the first tissue layer,
• wherein the electrostatic crosslinker is selected from the group consisting of magnesium chloride (MgCl2), strontium chloride (SrCl2), barium chloride (BaCl2), barium sulfate (BaSO4), calcium carbonate (CaCo3), ferric chloride (FeCl3) and ferrous chloride (FeCl2).