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US 11,452,797 B2Granted
Use of perfusion decellularized liver for islet cell recellularization
AssigneeMiromatrix Medical Inc.
InventorJeffrey Ross
Life of this patent
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Abstract
The invention provides a method to prepare a graft comprising a recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof, and a method of using the recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof.
Claims17
A method comprising:
- introducing to a mammal that has Type 1 diabetes or Type 2 diabetes a re-endothelialized extracellular matrix of a mammalian liver or portion thereof, wherein the re-endothelialized extracellular matrix comprises a first population of engrafted mammalian cells and a second population of engrafted mammalian cells,
- wherein the first population of mammalian cells comprises endothelial cells, stem cells, endothelial progenitor cells, or any combination thereof, and
- wherein the second population of mammalian cells comprises insulin producing cells, and wherein the first population of mammalian cells or the second population of mammalian cells are xenogeneic to the extracellular matrix of the mammalian liver or a portion thereof, thereby at least partially treating the Type 1 diabetes or the Type 2 diabetes.
A method comprising:
- introducing to a mammal that has Type 1 diabetes or Type 2 diabetes a re-endothelialized extracellular matrix of a decellularized extracellular matrix of a mammalian liver or a portion thereof, wherein the re-endothelialized extracellular matrix comprises a population of engrafted insulin producing cells, and wherein the engrafted insulin producing cells are xenographic to the decellularized extracellular matrix of the mammalian liver or portion thereof, thereby at least partially treating the Type 1 diabetes or the Type 2 diabetes.
Dependencies are inferred from the claim text.