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US 11,452,796 B2Granted
Cellular bone grafts, and methods of manufacture and use
AssigneeAlloSource
InventorsReginald Stilwell, Ramasamy Sakthivel, William Maslanik
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Abstract
The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.
Claims30
A method of manufacturing a bone graft material, the method comprising:
- combining a radiopaque component with a cancellous bone component to produce the bone graft material, wherein the cancellous bone component comprises native osteoreparative cells and less than 5% CD4+ cells, less than 5% CD3+ cells, and less than 5% CD45+ cells, and
- wherein the radiopaque component comprises particles having an average diameter from 100 microns to 4 mm, and the cancellous bone component comprises a particle size between 1 mm and 4 mm.
A bone graft material, comprising:
- a radiopaque component;
- and
- a cancellous bone component,
- wherein the cancellous bone component comprises native, osteoreparative cells and less than 5% CD4+ cells, less than 5% CD3+ cells, and less than 5% CD45+ cells, and
- wherein the radiopaque component comprises particles having an average diameter from 100 microns to 4 mm, and the cancellous bone component comprises a particle size between 1 mm and 4 mm.
2 more elements
Dependencies are inferred from the claim text.