Method for synthesizing a new ferrihydrite nano-photosensitizer and its antibacterial and anticancer use

Abstract

The present invention discloses a method for synthesizing a new ferrihydrite nano-photosensitizer, comprising steps of: weighing 303 mg of Fe(NO3)3⋅9H2O solid dissolved fully in 30 ml of distilled water to prepare a 0.75 mM of Fe(NO3)3 solution in water; adding PEG solid to the solution in water by stirring to fully dissolve at a molar ratio of PEG to Fe3+ of 1:1-1:50; stirring the obtained solution under heating at 75° C. in a water bath for 10-50 minutes, and then immediately cooling in an ice bath after removing; centrifuging and washing the cooled mixed solution at high speed under low temperature with the supernatant discarded, to obtain pellets as PEG-modified ferrihydrite nanoparticles (PEG-Fns). The PEG-Fns synthesized in the present invention can be controllably induced and reduced by blue light to release Fe2+, and then produce ⋅OH through Fenton reaction of Fe2+ and H2O2 in the cell, which induces cell oxidative damage, thereby achieving controllable anticancer and antibacterial purposes.

Dependencies are inferred from the claim text.