RSV immunization regimen
AssigneeGlaxosmithkline Biologicals SA
InventorPhilip Dormitzer
Life of this patent
Estimating the term…
Abstract
The invention relates to an immunization regimen whereby an infant is protected against respiratory syncytial virus (RSV) through administration of a first anti-RSV immune response inducing composition to his or her mother during pregnancy, followed by administration of a second anti-RSV immune response inducing composition to the infant after birth.
Claims18
A method for providing protective immunity against RSV in an infant, comprising
- (a) administering a first anti-RSV immune response inducing composition to a female during pregnancy, wherein the first anti-RSV immune response inducing composition comprises an RSV nucleic acid that encodes a RSV-F protein or fragment thereof, a recombinant viral vector that encodes a RSV-F protein or fragment thereof, or a viral replication particle that encodes a RSV-F protein or fragment thereof;
- and
- (b) administering a second anti-RSV immune response inducing composition to the infant that is born from the pregnancy, wherein the second anti-RSV immune response inducing composition comprises an RSV nucleic acid that encodes a RSV-F protein or fragment thereof, a recombinant viral vector that encodes a RSV-F protein or fragment thereof, or a viral replication particle that encodes a RSV-F protein or fragment thereof;
- wherein the first anti-RSV immune response inducing composition comprises a ribonucleic acid (RNA) that encodes a RSV-F protein or fragment thereof, the second anti-RSV immune response inducing composition comprises an RNA that encodes a RSV-F protein or fragment thereof, or the first and second anti-RSV immune response inducing compositions each comprise an RNA that encodes a RSV-F protein or fragment thereof.
A method for protecting an infant from disease caused by RSV, comprising administering to an infant a second anti-RSV immune response inducing composition comprising an RSV nucleic acid, a recombinant viral vector, or a viral replication particle;
- wherein said infant was born to a female to whom an anti-RSV immune response inducing composition comprising a first RSV nucleic acid that encodes a RSV-F protein or fragment thereof, a recombinant viral vector that encodes a RSV-F protein or fragment thereof, or a viral replication particle that encodes a RSV-F protein or fragment thereof, was administered during the time when said female was pregnant with said infant;
- wherein the first anti-RSV immune response inducing composition comprises an RNA that encodes a RSV-F protein or fragment thereof, the second anti-RSV immune response inducing composition comprises an RNA that encodes a RSV-F protein or fragment thereof, or the first and second anti-RSV immune response inducing compositions each comprise an RNA that encodes a RSV-F protein or fragment thereof.
Dependencies are inferred from the claim text.