Live-attenuated yellow fever virus strain adapted to grow on Vero cells and vaccine composition comprising the same
AssigneeSanofi Pasteur Limited
InventorsManuel Vangelisti, Nathalie Mantel, Yves Girerd-Chambaz, Fabienne Piras
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Abstract
The invention relates to a live-attenuated yellow fever virus strain adapted to grow on Vero cells from a parent yellow fever virus 17D substrain that is not adapted to grow on Vero cells, wherein said live-attenuated yellow fever virus strain is less neurovirulent than said parent yellow fever virus 17D substrain.
Claims15
A live-attenuated yellow fever virus strain which comprises an envelope protein comprising a leucine residue at the position within the protein that corresponds to position 480 of SEQ ID NO. 15, wherein the envelope protein comprises a sequence that is at least 90%, 95%, 98% or 100% identical to the sequence of SEQ ID NO. 15.
Dependencies are inferred from the claim text.