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US 11,452,771 B2Granted
Scaffolded HIV-1 Env GP140 trimer immunogen
AssigneeThe Scripps Research Institute
InventorsJiang Zhu, Linling He
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AssigneeThe Scripps Research Institute
InventorsJiang Zhu, Linling He
Estimating the term…
The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.
A polynucleotide sequence encoding a HIV-1 vaccine immunogen that comprises an HIV-1 Env-derived trimer protein presented on a self-assembling nanoparticle, wherein a linker sequence (a) is fused to the C-terminus of the nanoparticle subunit while the HIV-1 trimer protein subunit is fused to the N-terminus of the nanoparticle subunit or (b) links the HIV-1 trimer protein to the N-terminus of the nanoparticle subunit, wherein the self-assembling nanoparticle has a subunit sequence as shown in any one of SEQ ID NOs:6-17 or a conservatively modified variant thereof.
Dependencies are inferred from the claim text.