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AssigneeKolon Life Science, Inc.
InventorsSujeong Kim, Minjung Kim, Heonsik Choi, Jaeil Shin, Minju Kim, Hyesun Lee, Soondong Lee, Hwanjun Choi, Joonsung Kim, Jieun Hong, Eunjin Lee
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The present invention relates to a recombinant vaccinia virus in which the expression of some genes is inhibited, and a use thereof. The recombinant vaccinia virus of the present invention selectively kills cancer cells, and has an excellent reproducibility in cancer cells. Also, the virus has a lower toxicity to normal cells, and thus has an advantage of being safe for a human body. Therefore, the recombinant vaccinia virus of the present invention can be effectively used as a composition for treating cancer.
A method for treating a cancer in a subject in need thereof, comprising administering to the subject an effective amount of a recombinant vaccinia virus in which K3L gene, thymidine kinase (TK) gene, and vaccinia growth factor (VGF) gene are deleted or inactivated, wherein the recombinant vaccinia virus has an increased cancer cell killing activity in comparison to a recombinant vaccinia virus in which TK gene alone is deleted or inactivated, and the recombinant vaccinia virus has an increased cancer cell killing activity in comparison to a recombinant vaccinia virus in which VGF gene and TK gene are deleted or inactivated.
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