Inhibiting FAK-AKT interaction to inhibit metastasis

A method of reducing metastasis of cancer cells in a mammal comprising administering one or more inhibitors of FAK/Akt1 to a mammal in an amount sufficient to reduce metastasis of cancer cells in the mammal, wherein the inhibitor is:

• one or more compounds with the following structure:
• wherein:
• Ring A and Ring C independently are each an aryl ring;
• Ring B is a cycloalkyl ring;
• R1 is a lower alkyl or lower alkoxy;
• X is a C1 to C4 alkyl linker comprising a carbonyl, a carboxylate, an amide, a carboxylate(amino), or an aminocarboxylate group or a ═N—O—SO2— linker;
• and
• R2 and R3 are independently each a carboxylate, an amide, or a nitro group.