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US 11,452,760 B2Granted
Systems and methods for improved delivery of osteoinductive molecules in bone repair
AssigneeBioventus, LLC
InventorsEric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
Life of this patent
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Abstract
Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
Claims11
A kit for use in forming an implant, the kit comprising:
- a first composition including an acid etched calcium ceramic granule having a specific surface area greater than 30 m2/g, a pH less than 7, and an interconnected network of micropores defining at least one surface on an interior of the granule, wherein said micropores prevent multinucleated osteoclasts from penetrating into the interior of the granules;
- and
- a second composition comprising a solution comprising an osteoinductive protein and a buffering agent having a pKa between 2.3 and 4.5, the solution having a pH of less than 4.0, wherein said second composition is separate from the first composition.
A kit for use in forming an implant, the kit comprising:
- a first composition including a calcium ceramic granule having a specific surface area greater than 30 m2/g, a pH less than 7, and an interconnected network of micropores defining at least one surface on an interior of the granule, wherein said micropores prevent multinucleated osteoclasts from penetrating into the interior of the granules;
- and
- a second composition comprising a solution comprising a buffering agent having a pKa between 2.3 and 4.5, the solution having a pH of less than 4.0;
- and
- a third composition comprising an osteoinductive protein wherein the first composition, second composition and third composition are maintained separately.
2 more elements
Dependencies are inferred from the claim text.