Antimicrobial peptide derived from LL37 peptide and uses thereof
AssigneeIndustry-Academic Cooperation Foundation, Chosun University
InventorsYoonkyung Park, Eunji Park
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Abstract
A novel antimicrobial peptide derived from LL37 peptide has not only an excellent antimicrobial activity for Gram-positive bacteria, Gram-negative bacteria, and antibiotic tolerant bacteria but also low cytotoxicity for cells derived from mouse or human. It can be advantageously used as an effective component of antimicrobial antibiotics, cosmetic composition, food additive, animal feed additive, biopesticides, and quasi-drug.
Claims7
A method for antimicrobial treatment in a subject, the method comprising administering a composition comprising a pharmaceutically effective amount of an antimicrobial peptide in which, in the amino acid sequence of SEQ ID NO:
- 1, (i) the 1st to the 14th amino acids and the 31st to the 37th amino acids are deleted, and (ii) the 16th amino acid is substituted with lysine (K), or 16th and the 26th amino acids are substituted with lysine (K).
Dependencies are inferred from the claim text.