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US 11,452,748 B2Granted
Probiotic formulations and methods for use
AssigneesResearch Institute at Nation Children's Hospital, Ohio State Innovation Foundation
InventorsSteven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
Life of this patent
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Abstract
Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
Claims12
A microsphere composition comprising:
- a plurality of microspheres, each microsphere comprising dextran cross-linked with epichlorohydrin;
- a water-soluble carbohydrate that diffuses from within the microsphere selected from the group consisting of maltose, sucrose, and combinations thereof;
- L. reuteri strain ATCC 23272, wherein the L. reuteri is adhered to the surface of each microsphere;
- and
- a pharmaceutically acceptable carrier.
2 more elements
A microsphere composition comprising:
- a plurality of microspheres, each microsphere comprising dextran cross-linked with epichlorohydrin, and a water-soluble carbohydrate that diffuses from within the microsphere;
- L. reuteri adhered to the surface of each microsphere;
- and
- a pharmaceutically acceptable carrier.
1 more element
A microsphere composition comprising:
- a plurality of microspheres, each microsphere comprising a biodegradable polymer, and a water-soluble carbohydrate that diffuses from within the microsphere;
- L. reuteri strain ATCC 23272 adhered to the surface of each microsphere;
- and
- a pharmaceutically acceptable carrier.
1 more element
Dependencies are inferred from the claim text.