Applications of desogestrel in the preparation of breast cancer ER-negative Ah receptor-positive products
AssigneeShanghai Jiao Tong University
InventorsYongyong Shi, Zhijian Song
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Abstract
This invention discloses applications of desogestrel in the preparation of anti-colon cancer/breast cancer ER-negative Ah receptor-positive products. This invention provides applications for desogestrel in the preparation of products to treat colon cancer and/or breast cancer. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug desogestrel, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that desogestrel has a new use as an anti-colon cancer medication, thus achieving a new purpose for an old drug.
Claims5
A method for treating metastatic adenocarcinoma breast cancer in a subject comprising administering an effective amount of desogestrel to the subject.
A method of inhibiting the proliferation of metastatic adenocarcinoma breast cancer cells comprising contacting the cells with an effective amount of desogestrel.
A method of inhibiting the proliferation of MDA-MB-468 breast cancer cells comprising contacting the cells with an effective amount of desogestrel.
Dependencies are inferred from the claim text.