Methods for treating amyotrophic lateral sclerosis
AssigneeThe Regents of the University of Michigan
InventorsEva L. Feldman, Ben Murdock, Stephen Goutman, Stacey Jacoby
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Abstract
Provided herein are methods for treating, delaying progression of, or reducing the severity of amyotrophic lateral sclerosis (ALS) in a subject through administration of therapeutically effective amounts of agents (e.g., JAK kinase inhibitors (e.g., tofacitinib)) capable of interfering with central nervous system related natural killer cell (NK) levels and function.
Claims7
A kit comprising a therapeutically effective amount of an agent capable of interfering with central nervous system related natural killer cell (NK) levels and function and instructions for administering the agent to a subject having or at risk of having ALS, wherein the agent is a JAK kinase inhibitor, wherein the agent is selected from AT9283, AZD1480, baricitinib, BMS-911543, fedratinib, filgotinib (GLPG0634), gandotinib (LY2784544), INCB039110, lestaurtinib, momelotinib (CYT0387), NS-018, pacritinib (SB1518), peficitinib (ASP015K), ruxolitinib, tofacitinib (formerly tasocitinib), and XL019.
Dependencies are inferred from the claim text.