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US 11,452,720 B2Granted
Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
AssigneeGlobal Blood Therapeutics, Inc.
InventorsZhe Li, Stephan D. Parent, Travis Houston
Life of this patent
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Abstract
Disclosed are crystalline free base ansolvate forms of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (or Compound 1), such as the free base Form I, Form II and Material N. Also disclosed are crystalline free base solvates of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (or Compound 1).
Claims14
A method for treating sickle cell disease, comprising administering to a patient in need thereof:
- a composition comprising a crystalline ansolvate of Compound 1:
- characterized by X-ray powder diffraction peaks (Cu Kα radiation) at 13.37°, 14.37°, 19.95° and 23.92° 2θ (each ±0.2° 2θ), wherein the composition is substantially free of other ansolvate polymorphs of Compound 1;
- and
- another active agent.
1 more element
A pharmaceutical composition comprising:
- a composition comprising a crystalline ansolvate of Compound 1:
- characterized by X-ray powder diffraction peaks (Cu Kα radiation) at 13.37°, 14.37°, 19.95° and 23.92° 2θ (each ±0.2° 2θ), wherein the composition is substantially free of other ansolvate polymorphs of Compound 1;
- and
- another active agent.
1 more element
Dependencies are inferred from the claim text.