Pharmaceutical compositions of tedizolid phosphate
AssigneeMerck Sharp & Dohme Corp.
InventorsLixia Cai, David Dubost, David Harris, Yongjun Li, Majid Mahjour, Dan Zhang
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Abstract
Disclosed are pharmaceutical compositions comprising tedizolid phosphate, methods of preparing such pharmaceutical compositions, and methods of treating bacterial infections with such pharmaceutical compositions. Specifically, a pharmaceutical composition comprising tedizolid phosphate, an acid; and a suspending agent; and wherein the pH of the composition upon constitution with water is between about pH 2-4.5, is provided, wherein the acid is not citric acid or malic acid.
Claims24
A pharmaceutical composition comprising:
- (a) about 1-28% by weight of tedizolid phosphate, or a pharmaceutically acceptable salt thereof;
- and
- (b) about 0.2-14% by weight of a suspending agent;
- and
- wherein the pH of the composition upon constitution with water is between about pH 3-5.5.
A pharmaceutical composition comprising:
- a) about 1-28% by weight of tedizolid phosphate;
- b) about 0.2-14% by weight of an acid;
- c) about 0.2-14% by weight of a suspending agent;
- d) about 45-98.5% by weight of a filler;
- e) about 0.1-7% by weight of a glidant;
- and
- f) optionally about 0.1-4% by weight of an antimicrobial agent;
- and
- wherein the pH of the composition upon constitution with water is between about pH 3-5.5, provided that the acid is not citric acid or malic acid.
A pharmaceutical composition comprising:
- a) about 1.5-10% by weight of tedizolid phosphate;
- b) about 0.8-4% by weight of an acid;
- c) about 0.5-3% by weight of a suspending agent;
- d) about 80-96% by weight of a filler;
- e) about 0.3-1.5% by weight of a glidant;
- and
- f) optionally about 0.2-1% by weight of an antimicrobial agent;
- and
- wherein the pH of the composition upon constitution with water is between about pH 3-5.5, provided that the acid is not citric acid or malic acid.
Dependencies are inferred from the claim text.