Antibacterial agents including histidine kinase inhibitors
AssigneeRegents of the University of Minnesota
InventorsErin E. Carlson, Manibarsha Goswami
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Abstract
An example composition includes a therapeutically effective amount of a histidine kinase inhibitor. The histidine kinase inhibitor includes at least one of a 6-benzo[d]thiazol-2-amine derivative, a purine derivative, an adenine derivative, an adenine-sulfonyl fluoride derivative, a riluzole analog, a riluzole-sulfonyl fluoride derivative, a 6-benzo[d]thiazol-2-amine-sulfonyl fluoride derivative, a 6,6′-oxybis(benzo[d]thiazol-2-amine) derivative, or a 6,6′-oxybis(benzo[d]thiazol-2-amine)-sulfonyl fluoride derivative. An example technique for treating a bacterial infection includes administering a composition comprising a histidine kinase inhibitor to a patient.
Claims15
A composition comprising a therpeutically effective amount of a histidine kinase inhibitor for treating a bacterial infection, wherein the histidine kinase inhibitor comprises a riluzole analog having a structure
- where R═Cl, R1═H, R2═H, R3═NH2;
- or R═CF3, R1═H, R2═H, R3═NH2;
- or R═NH2, R1═H, R2═H, R3═CH3;
- or R═OCH3, R1═H, R2═H, R3═NH2;
- or R═NH2, R1═H, R2═H, R3═NH2;
- or R═NHCH2-arylsulfonyl fluoride, R1═H, R2═H, R3═NH2;
- or R═NHC(O)-arylsufonyl fluoride, R1═H, R2═H, R3═NH2.
A composition comprising a therapeutically effective amount of a histidine kinase inhibitor for treating a bacterial infection, wherein the histidine kinase inhibitor comprises a 6-benzo[d]thiazol-2-amine derivative having a structure
- where R═Cl, OCH3, or CF3.
A composition comprising a therapeutically effective amount of a histidine kinase inhibitor for treating a bacterial infection, wherein the histidine kinase inhibitor comprises a 6,6′-oxybis(benzo[d]thiazol-2-amine) derivative having a structure
- where R═COCH3 or
Dependencies are inferred from the claim text.