Chemotherapeutic methods for treating low-proliferative disseminated tumor cells
AssigneeUniversity of Florida Research Foundation, Inc.
InventorDavid Tran
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Abstract
Disclosed herein are chemotherapeutic methods for the treatment of cancer in humans. In at least one specific embodiment, the method can include administering a therapeutic effective amount of one or more p38 inhibitor compound or salt thereof to a human. The method can also include administering a therapeutic effective of one or more IL-6 inhibitor or one or more IL-6 receptor inhibitor or salt thereof to the human. The method can also include administering a therapeutic effective amount of one or more cytotoxic compound or salt thereof to the human.
Claims8
A method of treating a subject having TWIST1 positive low-proliferative disseminated tumor cells (lpDTCs), comprising:
- administering to the subject a therapeutic effective amount of one or more anti-IL-6 receptor (IL-6R) antibodies, and
- administering to the subject a therapeutic effective amount of one or more anticancer cytotoxic drugs or salts thereof,
- wherein the one or more anti-IL-6 receptor antibodies are administered about 1 hour to about 1 week prior to administration of the one or more cytotoxic drugs or salts thereof, and
- wherein administration of the one or more anti-IL-6 receptor (IL-6R) antibodies prior to administration of the one or more cytotoxic drugs or salts thereof increases sensitivity of the lpDTCs to the one or more cytotoxic drugs or salts thereof.
Dependencies are inferred from the claim text.