Compositions and methods for preventing and treating radiation-induced bystander effects caused by radiation or radiotherapy
AssigneesThe Regents of the University of Colorado, a body corporate, Tsinghua University, Chang Gung University
InventorsDing Xue, Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jau-Song Yu, Jeng-Ting Chen
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Abstract
The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
Claims9
A method for treating radiation-induced bystander effects (RIBE) in non-irradiated cells of a subject caused by exposure to radiation, comprising administering to the subject a therapeutically effective amount of quercetin, isoquercetin, or a combination thereof, wherein said therapeutically effective amount inhibits the activity of Cathepsin B (CTSB), preventing RIBE in said non-irradiated cells.
Dependencies are inferred from the claim text.