Discovery of potent [alpha]-glucosidase inhibitors from Heterophragma adenophyllum
AssigneeKing Abdulaziz University
InventorsAbdur Rauf, Zafar Ali Shah, Yasir Anwar, Abdul Wadood, Hani Mohammed Ali, Abdurahman Labeed Almalki, Khalid Mohammed S. Al-Ghamdi
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Abstract
A family of α-glucosidase inhibitors are identified. Exemplary α-glucosidase inhibitors may be obtained from Heterophragma adenophyllum seem. The inhibitors are used to lower blood sugar levels and thus to treat diseases related to or characterized by high blood sugar, such as diabetes.
Claims9
A method of inhibiting α-glucosidase, comprising:
- contacting the α-glucosidase in vitro with the following compound:
- methyl 1,2-dihydroxy-2-(3-methylbut-2-enyl)-3-oxo-2,3-dihydroxo-1H-indene-1-carboxylate, wherein said compound is purified to 90-100% purity.
A method of stabilizing or decreasing blood sugar levels in a subject in need thereof, comprising:
- administering a therapeutically effective amount of the following compound:
- methyl 1,2-dihydroxy-2-(3-methylbut-2-enyl)-3-oxo-2,3-dihydroxo-1H-indene-1-carboxylate, wherein the compound is in a pharmaceutically acceptable form and has a purity of 90-100%, and wherein the compound is administered multiple times.
A method of treating diabetes mellitus in a subject in need thereof, comprising:
- administering to a subject in need thereof 1 to 100 mg of the following compound:
- methyl 1,2-dihydroxy-2-(3-methylbut-2-enyl)-3-oxo-2,3-dihydroxo-1H-indene-1-carboxylate, wherein the compound is in a pharmaceutically acceptable form and has a purity of 90-100%, and wherein the compound is administered multiple times.
Dependencies are inferred from the claim text.