Oral drug delivery composition containing oxaliplatin and method for preparing same
AssigneeIcure Bnp Co., Ltd.
InventorsJin Woo Park, Young Ro Byun, Young Kweon Choi, Kwan Young Chang, Jae Bum Lee
Life of this patent
Estimating the term…
Abstract
Provided are an oral delivery composition including oxaliplatin, a water-soluble anticancer agent, and a preparation method thereof, including forming an ionic complex with a bile acid derivative, which is an oral absorption promoter, and oxaliplatin, and incorporating it into the inner aqueous phase of a water-in-oil-in-water (w/o/w) multiple nanoemulsions, thereby obtaining the oral delivery composition with improved oral bioavailability of oxaliplatin, a water-soluble anticancer agent, avoiding the inconvenience and problems of injection, improving patient compliance, and reducing medical costs.
Claims14
A method of preparing an oral delivery composition comprising oxaliplatin, comprising:
- (a) adding a positively charged bile acid derivative to oxaliplatin to form an ion-pairing complex;
- (b) adding a mixture of a primary surfactant and a primary co-surfactant to a primary oil phase;
- (c) mixing the ion-pairing complex with the mixture resulting from step (b) to obtain a water-in-oil (w/o) primary nanoemulsion;
- (d) adding a mixture of a secondary surfactant and a secondary co-surfactant to the w/o primary nanoemulsion to obtain a water-in-oil-in-water (w/o/w) secondary nanoemulsion.
Dependencies are inferred from the claim text.