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US 11,452,702 B2Granted
Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases
AssigneeProfessional Dietetics International S.r.l.
InventorPaolo Luca Maria Giorgetti
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Abstract
Composition for promoting mitochondrial biogenesis and improving mitochondrial function in a subject, the composition comprising an active agent, said active agent containing the amino acids leucine, isoleucine, valine, threonine, lysine and citric acid, succinic acid, malic acid.
Claims17
A method of treatment for obesity, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising an active agent, said active agent comprising leucine, isoleucine, valine, threonine, lysine, citric acid, succinic acid and malic acid,
- wherein the citric acid:malic acid:succinic acid weight ratio is between 10:1:1 and 1:3:1:1,
- wherein the composition comprises the amino acids isoleucine, leucine and valine in an amount by weight between 35% and 65%,
- wherein the weight ratio between (i) the sum of citric acid, malic acid and succinic acid and (ii) the sum of leucine, isoleucine and valine is between 0.1 and 0.4,
- wherein the weight ratio between (i) the sum of citric acid, malic acid and succinic acid and (ii) the sum of leucine, isoleucine, valine, lysine and threonine is between 0.05 and 0.3 and
- wherein the weight ratio between leucine and citric acid is comprised between 5 and 1.
2 more elements
Dependencies are inferred from the claim text.