Method of delivering an anesthetic agent and glucocorticoid micro and nano bioerodible particles
OwnerEric Haasinventor
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Abstract
The present disclosure provides polymeric particles and scaffolds comprising a matrix and an anesthetic agent. In one embodiment, the matrix comprises a bioerodible polymer. The disclosure further relates to the use of the polymeric particles and scaffolds for sustained local delivery of anesthetic agents, reduction of pain killer addiction and addiction risk. The disclosure also provides methods of fabricating and administering polymeric particles and scaffolds containing an anesthetic agent described herein.
Claims6
A method of delivering an anesthetic agent to a subject in need thereof, comprising administering to the subject one or more drug delivery particles, or a drug delivery scaffold, comprising a polymer matrix and an anesthetic agent selected from the group consisting of benzocaine, chloroprocaine, cyclomethycaine, dimethocaine, piperocaine, propoxycaine, procaine, proparacaine, tetracaine, articaine, bupivacaine, cinchocaine, etidocaine, levobupivacaine, lidocaine, mepivacaine, prilocaine, ropivacaine, and trimecaine, wherein after administration the polymer matrix is gradually bioeroded and the anesthetic agent is sustainably released, and wherein the drug delivery particles or drug delivery scaffold further comprises 0.01 to 30% by weight of a glucocorticoid or wherein 0.01 to 30% by weight of a glucocorticoid is co-administered to the subject with the drug delivery particles or drug delivery scaffold.
Dependencies are inferred from the claim text.