Dissolvable gel-forming film for delivery of active agents
AssigneeSmith & Nephew, Inc.
InventorsLei Shi, Aleksa Jovanovic, Dennis Carson
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Abstract
Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
Claims31
A dissolvable, gel-forming film comprising:
- (a) a water-soluble cellulose ether;
- (b) a hydrophilic rheological modifying agent;
- and
- (c) a thermolysin or collagenase proteolytic enzyme,
- wherein the dissolvable, gel-forming film has a water content of less than 15% w/w, and the dissolvable, gel-forming film is capable of forming a hydrogel having a viscosity of 1,000 to 100,000 cps, as measured using a Brookfield RV Model Viscometer using small sample adapter with spindle #SC4-14 and chamber #SC4-6R, at 10 rpm at room temperature, reading taken at 1 minute, when 1 gm of gel-forming film is contacted with 20 ml of water or other aqueous medium.
A dissolvable, gel-forming film comprising:
- (a) 25 to 35% w/w of hydroxyethylcellulose and 25 to 35% w/w of hydroxypropylmethyl cellulose;
- (b) 15 to 25% w/w of a polyethylene glycol;
- and
- (c) 5 to 15% w/w of thermolysin,
- wherein the dissolvable, gel-forming film has a water content of less than 15% w/w, and the dissolvable, gel-forming film is capable of forming a hydrogel when 1 gm of gel-forming film is contacted with 20 ml of water or other aqueous medium.
Dependencies are inferred from the claim text.