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US 11,452,691 B1Granted
Compositions of bupivacaine multivesicular liposomes
AssigneePacira Pharmaceuticals, Inc.
InventorsJeffrey S. Hall, David J. Turnbull, John J. Grigsby, Jr., Soroush M. Ardekani, Kathleen D. A. Los
Life of this patent
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Abstract
Embodiments of the present application relate to compositions of multivesicular liposomes (MVLs) and manufacturing processes for making bupivacaine MVLs.
Claims58
Batches comprising compositions of bupivacaine multivesicular liposomes (MVLs), comprising:
- bupivacaine residing inside a plurality of internal aqueous chambers of the MVLs separated by lipid membranes, wherein the lipid membranes comprise 1, 2-dierucoylphosphatidylcholine (DEPC), 1, 2-dipalmitoyl-sn-glycero-3 phospho-rac-(1-glycerol) (DPPG), and at least one neutral lipid;
- and
- an aqueous medium in which the bupivacaine encapsulated MVLs are suspended;
- wherein the rate of hydrolysis of DEPC as measured by an erucic acid concentration is less than about 18.75 μg/mL/month after the compositions are stored at 25° C. for six months.
1 more element
Dependencies are inferred from the claim text.