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US 11,452,690 B1Granted
Oral liquid compositions comprising amlodipine besylate and methods of using the same
AssigneeEci Pharmaceuticals, LLC
InventorsNirali R. Bhatt, Alok Kapadia
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Abstract
The present disclosure provides oral liquid compositions comprising amlodipine besylate with favorable solubility and stability. Also provided herein are methods of using the oral liquid compositions.
Claims24
An oral liquid pharmaceutical composition consisting of:
- about 0.1 to about 1.9 mg/mL amlodipine besylate;
- about 5 mg/mL to about 90 mg/mL cyclodextrin;
- about 0.5 mg/mL to about 4 mg/mL paraben;
- optionally, at least one additional preservative;
- optionally, at least one sweetener;
- optionally, at least one flavoring agent;
- optionally, at least one coloring agent;
- and
- water.
6 more elements
An oral liquid pharmaceutical composition consisting of:
- about 0.8 to about 1.2 mg/mL amlodipine besylate;
- about 10 mg/mL to about 60 mg/mL cyclodextrin;
- about 1.5 mg/mL to about 2.5 mg/mL paraben;
- optionally, at least one additional preservative;
- optionally, at least one sweetener;
- optionally, at least one flavoring agent;
- optionally, at least one coloring agent;
- and
- water;
- provided that a volume of the oral liquid pharmaceutical composition retains at least 90% of an initial concentration of amlodipine besylate after the volume has been stored in a sealed container for three months at 23° C. to 27° C. and 55% to 65% relative humidity.
7 more elements
Dependencies are inferred from the claim text.