Transdermally absorbable base material containing lipid peptide compound

A method of transdermally absorbing an active component, the method comprising:

• applying a composition comprising a lipid peptide compound of Formula (1) or pharmaceutically usable salts thereof, a surfactant, an 1,2-alkanediol or a glycerin, at least one fatty acid, water, and the active component to skin,
• wherein R1 is a C9-23 aliphatic group;
• R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a branched chain having a carbon atom number of 1 or 2;
• R3 is a —(CH2)—X group;
• n is a number of 1 to 4;
• and X is amino group, guanidino group, —CONH2 group, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms;
• wherein the active component is selected from hyaluronic acid and insulin,
• wherein the at least one fatty acid is selected from among the group consisting of capric acid, myristic acid, palmitic acid, and stearic acid, and
• wherein the surfactant is at least one of an ethylene glycol alkyl ether, a phospholipid, and a polyglycerin fatty acid ester;
• and
• allowing the active component to transdermally absorb into the skin.