Back to results
US 11,452,682 B2Granted
Toothpaste composition for alleviating dentin hyperesthesia
AssigneeHysensbio
InventorsJoo Hwang Park, Ji Hyun Lee
Life of this patent
Estimating the term…
Abstract
A toothpaste composition for alleviating dentin hyperesthesia is disclosed. The composition includes a peptide consisting of an amino acid sequence of the following Formula 1: K-Y-R1-R2-R3-R4-R5-R6-R7-R8 (Formula 1) wherein R1 is arginine (R), lysine (K) or glutamine (Q); R2 is arginine (R) or glutamine (Q); R3, R4, and R5 are arginine (R) or lysine (K), respectively; R6 is asparagine (N) or serine (S); and R7 and R8 are lysine (K) or tyrosine (Y), respectively.
Claims8
A toothpaste composition for alleviating dentin hyperesthesia, comprising a peptide consisting of an amino acid sequence of the following Formula 1:
- K-Y-R1-R2-R3-R4-R5-R6-R7-R8 (Formula 1)
- wherein R1 is arginine (R), lysine (K) or glutamine (Q);
- R2 is arginine (R) or glutamine (Q);
- R3, R4, and R5 are arginine (R) or lysine (K), respectively;
- R6 is asparagine (N) or serine (S);
- and
- R7 and R8 are lysine (K) or tyrosine (Y), respectively,
- wherein said toothpaste composition includes 0.0015-0.0025 parts by weight of the peptide, 31.00-33.00 parts by weight of tricalcium phosphate, 0.045-0.055 parts by weight of hydroxyapatite, and 20-22 parts by weight of purified water,
- wherein said toothpaste composition forms a thin film on the surface of said dentin and induces remineralization on said surface of said dentin and dentinal tubule by binding with the phosphate-calcium ions released from said tricalcium phosphate.
6 more elements
Dependencies are inferred from the claim text.