US 11,452,442 B2 · Systems and methods for automated widefield optical coherence tomography angiography

Abstract

Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

Claims32

Dependent claims

A system for wide-field optical coherence tomography angiography (OCTA) imaging of the retina comprising:

an optical coherence tomography (OCT) apparatus to acquire a plurality of OCT interferograms of a retina of an eye;
a fixation target module to set fixation targets for respective OCT interferograms of the plurality of OCT interferograms at a respective locations in a field of view;
an eye centering module to align a center of a pupil of the eye with respect, to a scanning beam of the OCT apparatus;
and
an iris plane module to position the pivot point of the scanning beam of the OCT apparatus at a plane of the pupil of the eye, wherein the iris plane module comprises:
a light source operationally coupled to a cylindrical lens, the light source to project an illumination line onto an iris of an eye;
a camera to capture a sequence of images of the eye;
a processor to analyze the sequence of images of the eye to measure the sharpness of the illumination line;
and
a controller to adjust the position of a translational stage to maximize the sharpness of the illumination line.

7 more elements

Dependencies are inferred from the claim text.

Systems and methods for automated widefield optical coherence tomography angiography

Life of this patent

Systems and methods for automated widefield optical coherence tomography angiography

Life of this patent

Abstract

Claims32