Method of selecting a probiotic

A method for the potentiation of at least one effect of oleuropein in an individual in need of at least one effect selected from the group consisting of a therapeutic effect against a condition, a reduction of risk of a condition, a reduction of severity of a condition, and/or a prophylactic effect of oleuropein in the individual,

• wherein the condition is selected from the group consisting of:
• (i) osteoporosis, Paget's disease, osteolysis adjacent a prosthesis, a metastatic bone disease, hyperthyroidism, hypercalcemia due to a cancer, multiple myelomas, a periodontal disease, osteoarthritis, osteopenia, a bone deficit resulting from a fracture, fracture healing, and combinations thereof;
• or
• (ii) lupus, gout, rheumatoid arthritis, osteoarthritis, osteochondritis disease, osteoarthrosis and combinations thereof,
• the method comprising co-administration of therapeutically effective amounts of:
• (a) a probiotic microorganism or a mixture of probiotic microorganisms, wherein the microorganism or microorganisms comprise a gene encoding β-glucosidase and a gene encoding an esterase that yields hydroxytyrosol acetate, hydroxytyrosol or elenolic acid as an esterase reaction product;
• and
• (b) oleuropein, to the individual in need thereof.